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ey0015.11-10 | Smelling, tasting and weight gain | ESPEYB15

11.10 The Sense of Smell Impacts Metabolic Health and Obesity

CE Riera , E Tsaousidou , J Halloran , P Follett , O Hahn , MMA Pereira , LE Ruud , J Alber , K Tharp , CM Anderson , H Brönneke , B Hampel , CDM Filho , A Stahl , JC Brüning , A Dillin

To read the full abstract: Cell Metab. 2017, Volume 26, Issue 1 Riera et al. developed ways to temporarily eliminate the sense of smell in adult mice. They discovered that mice lacking smell could eat a high-fat diet and stay significantly thinner than littermates with a normal sense of smell. Conversely, mice with hyperosmia gained more weight than wild-type mice on a high-fat diet. ...

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ey0017.14-12 | (1) | ESPEYB17

14.12. Brain-Sparing sympathofacilitators mitigate obesity without adverse cardiovascular effects

I Mahu , A Barateiro , E Rial-Pensado , N Martinez-Sanchez , SH Vaz , PMSD Cal , B Jenkins , T Rodrigues , C Cordeiro , MF Costa , R Mendes , E Seixas , MMA Pereira , N Kubasova , V Gres , I Morris , C Temporao , M Olivares , Y Sanz , A Koulman , F Corzana , AM Sebastiao , M Lopez , GJL Bernardes , AI Domingos

To read the full abstract: Cell Metab. 2020 Jun 2;31(6):1120-1135.e7. doi: 10.1016/j.cmet.2020.04.013.This experimental rodent study of a PEGylated amphetamine (PEGyAMPH) designed to not cross the blood brain barrier is interesting for 2 reasons. First, it shows that its peripheral anti-obesity effects alone (without the central anorexic effects of amphetamine) are sufficient to achieve...

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ESPE Yearbook of Paediatric Endocrinology

11.10 The Sense of Smell Impacts Metabolic Health and Obesity

14.12. Brain-Sparing sympathofacilitators mitigate obesity without adverse cardiovascular effects

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